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TOR SERINE-THREONINE KINASES
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DeCS
Descriptor
English
:
TOR Serine-Threonine Kinases
Descriptor
Spanish
:
Serina-Treonina Quinasas TOR
Descriptor
Portuguese
:
Serina-Treonina Quinases TOR
Synonyms
English
:
mTOR Serine-Threonine Kinases
TOR Kinases
Tree Number:
D08.811.913.696.620.682.700.931
D12.776.476.925
Definition
English
:
A
serine
threonine
kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of
RAPAMYCIN
due to the discovery that
SIROLIMUS
(commonly known as
rapamycin
) forms an inhibitory complex with
TACROLIMUS BINDING PROTEIN 1A
that blocks the action of its enzymatic activity.
History Note
English
:
2011
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
54051
Unique Identifier:
D058570
Occurrence in VHL
:
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